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Good news as WHO unveils drug to tackle excessive bleeding at childbirth

The World Health Organisation (WHO) says a new drug – Carbetocin – has the potential to save thousands of women’s lives in childbirth annually.

WHO said Carbetocin now serves as a new competition – with improved benefits – to Oxytocin, a standby drug used to prevent potentially-fatal bleeding after childbirth.

WHO said excessive bleeding after childbirth still kills around 70,000 mothers a year and currently, Oxytocin is the first-choice medication, but it must be kept cold, unlike the new drug, Carbetocin.

The study, partly led, among others, by WHO and published on Wednesday, suggested that the new drug which could be stored at normal temperatures, could save the lives of thousands in low- and lower-middle-income countries.

“This is a truly encouraging new development that can revolutionise our ability to keep mothers and babies alive,” said WHO Director-General Tedros Adhanom Ghebreyesus.

WHO said since Oxytocin must be stored and transported at a cool two to eight degrees Celsius – a difficult task in many countries – numerous women lack access to the medicine.

The global health agency said even if women could obtain Oxytocin, heat exposure might render the drug less effective.

The study, published in the New England Journal of Medicine, has shown the heat-stable Carbetocin is not only as safe and effective as Oxytocin but even without refrigeration – when stored at below 30 degrees Celsius and 75 percent relative humidity – it retains its efficacy for at least three years.

In the largest clinical trial of its kind, close to 30,000 women who gave birth vaginally were studied in Nigeria, Argentina, Egypt, India, Kenya, Singapore, South Africa, Thailand, Uganda and the United Kingdom.

Immediately after childbirth, each woman was randomly injected with a single dose of either heat-stable Carbetocin or Oxytocin – revealing that both were equally effective at preventing excessive bleeding.

Metin Gülmezoglu of WHO’s Department of Reproductive Health and Research described the report of Carbetocin as “very good news” for millions of women.

“The development of a drug to prevent postpartum haemorrhage that continues to remain effective in hot and humid conditions is very good news for the millions of women who give birth in parts of the world without access to reliable refrigeration,” Gülmezoglu said.

While Carbetocin has not yet been cleared for use beyond clinical trials, the next steps begin with a regulatory review, countries’ approval and then consideration by WHO’s Guideline Development Group.

However, WHO said that following the positive trial results, it would be working to advance affordable access to the potentially lifesaving drug in countries with a high maternal death rate.

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